Diabetic foot ulcer treatment with Persian Turpentine ointment

Diabetes has entered (2019) the top 10 causes of death.

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According to the information provided by the WHO (World Health Organization), about 422 million people worldwide have diabetes, the majority living in low-and middle-income countries, and 1.5 million deaths are directly attributed to diabetes each year. Both the number of cases and the prevalence of diabetes have been steadily increasing over the past few decades.

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Diabetic wounds are one of the types of chronic wounds that need specialized care.

Diabetic Foot Ulcer

A diabetic foot ulcer (DFU) is an open sore or wound that is commonly located on the bottom of the foot.

Diabetic ulcers, like other chronic ulcers, have the following consequences:

• Persistent infections
• Prolonged or severe inflammation
• The development of drug-resistant microbial biofilms
• The incapacity of dermal and/or epidermal cells to react to reparative stimuli

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Standard treatment of DFU (Diabetic Foot Ulcer) includes:

• Wound debridement
• Infection control
• Revascularization
• In general, the acceleration of the healing process

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The amputation approach does not resolve the risk of reinfection in patients who have diabetic foot ulcers, as they are still susceptible to a 40% mortality rate after amputation.

Diabetic foot ulcer treatment with Persian Turpentine

Recent studies have suggested that natural products could be used to treat wounds.

The therapeutic properties of herbal medicine are unique to the mixture of bioactive components. Among them, Flavonoids are one of the promising key bioactive ingredients for wound-healing properties. For this reason, Flavonoids are implemented in numerous formulations, topical ointments, and dressings for wound healing.

A study (2015) was conducted to evaluate the effect of anti-inflammatory Glycosylated Flavonoids on the treatment of Diabetes-Impaired Wounds.

«The results showed that the topical ointments containing flavonoids exert beneficial effects in wound healing process.»

Persian Turpentine (Mount Atlas Mastic Liquid) contains Flavonoids, Flavonoid glycosides, Terpenoids, and Phenolic Compounds with strong antioxidant and anti-microbial properties that can effectively wound healing process help.

Numerous studies have reported that flavonoids possess wound-healing properties due to their well-acclaimed anti-inflammatory, angiogenesis, re-epithelialization, and antioxidant effects.

Flavonoids increase the migration and proliferation of fibroblasts and collagen synthesis. Furthermore, most flavonoids exert antibacterial and astringent activities that help in infection control.

Bioactivity of flavonoids can vary according to source, chemical structure and glycosylation pattern.

In summary, topical application of flavonoids reduces epithelialization and wound closure time of DFU in diabetic patients.

Flavonoids, which are also present in the resin of P. atlantica, are one of the most important and promising families of natural compounds for treating skin lesions (Such as skin lesions caused by Rheumatic Skin Diseases).

Note: Studies have indicated that flavonoid glycosides contribute to the prevention of cancer, atherosclerosis, and chronic inflammation in humans by slowing down oxidative degradation.

A study (2018) was conducted to evaluate the effects of Pistacia atlantica resin oil (Persian Turpentine Oil) on the level of VEGF, Hydroxyproline, Antioxidant, and wound healing activity in STZ-induced diabetic rats.

«The results showed that Pistacia atlantica resin oil has remarkable antioxidant activity in STZ-induced diabetic rats.

Also, it promoted VEGF and hydroxyproline contents in the wound area which showed that it increases angiogenesis and collagen turnover in the diabetic wound.»

So Pistacia atlantica resin oil can be considered a new therapeutic agent in diabetic wound healing, and also it is a safe, available, and cheap treatment for other wounds and skin injuries.

Why Chronic Wound Care is Important?

Mobility limitations are one of the worst aspects of having a chronic wound, according to patients, as these limitations can impede independence and quality of life.

Chronic wounds place a significant financial strain on healthcare systems, in terms of both direct and indirect expenditures.

According to various research reports and data published by Mission Regional Medical Center in 2020, it was estimated that around 6.7 million people in the world were suffering from chronic wounds.

According to reports, more than 13 million people worldwide experience chronic wounds each year, and the number of patients affected is steadily growing as the world’s population ages.

The global chronic wound care market is projected to grow from USD 12.36 billion in 2022 to USD 19.52 billion by 2029, at a CAGR of 6.7% in the forecast period.

CAGR: The compound annual growth rate

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